(2012) Species Association of Hepatitis B Virus (HBV) in Non-Human Apes Evidence for Recombination between Gorilla and Chimpanzee Variants. Both of these observations provide evidence for circulation of HBV between different species and sub-species of non-human primates, a conclusion that differs from the hypothesis if of strict host specificity of HBV genotypes.Ĭitation: Lyons S, Sharp C, LeBreton M, Djoko CF, Kiyang JA, Lankester F, et al. The two gorilla viruses were phylogenetically distinct from chimpanzee and human variants although one showed evidence for a recombination event with a P.t.e.-derived HBV variant in the partial X and core gene region.
troglodytes HBV variants also grouped within this clade, indicative of transmission between sub-species, forming a paraphyletic clade. ellioti grouped with previously characterised variants from this subspecies. Complete genome sequences were obtained from six of the infected chimpanzee and both gorillas those from P. 9 of 62 chimpanzees (11.3%) and two from 11 gorillas (18%) were HBV-infected (15% combined frequency), while other Old world monkey species were negative. To investigate species-specificity and potential for cross species transmission of HBV between sympatric species of apes (such as gorillas and chimpanzees in Central Africa) or between humans and chimpanzees or gorillas, variants of HBV infecting captive wild-born non-human primates were genetically characterised.
HBV variants have also been detected and genetically characterised from Old World apes Gorilla gorilla (gorilla), Pan troglodytes (chimpanzee), Pongo pygmaeus (orang-utan), Nomascus nastusus and Hylobates pileatus (gibbons) and from the New World monkey, Lagothrix lagotricha (woolly monkey). Hepatitis B virus (HBV) infections are widely distributed in humans, infecting approximately one third of the world's population.
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